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MIAMI (CBSMiami) – Tickets have gone on sale at American Airlines for flights to five Cuban cities beginning this fall.

The air carrier, which has a major hub at Miami International Airport, expects to begin service from Miami to both Cienfuegos and Holguin on on Wednesday, September 7th. The first flight will depart from Miami to Cienfuegos at 10 a.m, pending the approval of Cuba’s government.

Flights from Miami to Camaguey and Santa Clara will begin on September 9th with flights to Varadero beginning September 11th.

Tickets are on sale on and can also be purchased through the airlines reservations department.

Miami and Ft. Lauderdale were two of five cities selected to have scheduled flights to Cuba beginning as early as this fall.

In addition to American Airlines, Frontier Airlines, JetBlue Airways, Silver Airways, Southwest Airlines and Sun Country Airlines were also chosen to run flights to the island nation. They will need to market and sell tickets consistent with the laws, regulations, and requirements that remain in affect concerning travel to Cuba. Travelers should check directly with the airlines for details.

Under the new arrangement with the Cuban government, each country has the opportunity to operate up to 10 daily roundtrip flights between the U.S. and each of Cuba’s nine international airports, other than Havana, for a total of 90 daily round trips.

The arrangement also provides for up to 20 daily round trip flights between the U.S. and Havana. The U.S. carriers have requested nearly 60 flights per day to Havana, so now the U.S. Department of Transportation will have to make selections from among the proposals. A decision on the Havana routes will be announced later this summer.