LOS ANGELES (CBSMiami/AP) —  Stand Up To Cancer is back in the spotlight.  The show is returning to prime time Friday night Sept. 5th on CBS, and just about any channel, to raise money and awareness for cancer research.

Dozens of broadcast and cable networks are once again donating a simultaneous hour of commercial-free airtime to carry the fundraiser “Stand Up to Cancer.”

Participants include CBS, ABC, Fox, NBC, HBO, Showtime, Lifetime, ESPNews and many others. A Canadian broadcast is being added this year.

Gwyneth Paltrow and Joel Gallen are returning to produce the telecast for a second time, and other stars from television, film and music will encourage and accept donations from the public.

Stars include Jennifer Aniston, Jon Hamm, Halle Berry, Reese Witherspoon and Kiefer Sutherland. They are just a few of the stars scheduled to appear on the telethon. Other celebrity participants include Pierce Brosnan, Rob Lowe, Will Ferrell, Ben Stiller, Eric Stonestreet and Kareem Abdul-Jabbar.

Rather than the stars staffing phone banks as they have on past “Stand Up to Cancer” telethons, they’ll be contacting with viewers by phone and online through Facebook and other platforms from a “digital lounge” hosted by Katie Couric. Fans can sign up for the “We’re Calling You” initiative at werecallingyou.org.

The “Stand Up to Cancer” special will also feature performances by Jennifer Hudson, Ariana Grande, The Who, Common & Lupe Fiasco and Dave Matthews.

Since its first broadcast in 2008, Stand Up to Cancer has pledged more than $260 million.

(© Copyright 2014 The Associated Press. All Rights Reserved. This material may not be published, broadcast, rewritten or redistributed.)

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